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Search: WFRF:(Krogh Vittorio) > Agudo Antonio > Saracci Rodolfo > Overvad Kim > Vineis Paolo > Martínez Carmen > (2010) > Physical activity a...

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Physical activity and lung cancer among non-smokers : a pilot molecular epidemiological study within EPIC

Rundle, Andrew (author)
Richie, John (author)
Steindorf, Karen (author)
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Peluso, Marco (author)
Overvad, Kim (author)
Raaschou-Nielsen, Ole (author)
Clavel-Chapelon, Francoise (author)
Linseisen, Jacob P. (author)
Boeing, Heiner (author)
Trichopoulou, Antonia (author)
Palli, Domenico (author)
Krogh, Vittorio (author)
Tumino, Rosario (author)
Panico, Salvatore (author)
Bueno-De-Mesquita, Hendrik B. (author)
Peeters, Petra H. (author)
Lund, Eiliv (author)
Gonzalez, Carlos A. (author)
Martinez, Carmen (author)
Dorronsoro, Miren (author)
Barricarte, Aurelio (author)
Jose Tormo, M. (author)
Quiros, Jose R. (author)
Agudo, Antonio (author)
Berglund, Göran (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Järvholm, Bengt (author)
Umeå universitet,Näringsforskning
Bingham, Sheila (author)
Key, Timothy J. (author)
Gormally, Emmanuelle (author)
Saracci, Rodolfo (author)
Kaaks, Rudolf (author)
Riboli, Elio (author)
Vineis, Paolo (author)
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 (creator_code:org_t)
2010-01-06
2010
English.
In: Biomarkers. - : Taylor & Francis. - 1354-750X .- 1366-5804. ; 15:1, s. 20-30
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 μmol GSH g-1 haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)

Keyword

Physical activity
lung cancer
biomarkers
molecular epidemiology
biomarkers
Physical activity
lung cancer
molecular epidemiology

Publication and Content Type

ref (subject category)
art (subject category)

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